Immunization of Ferrets against Influenza: A Comparison of Killed Ferret Grown and Egg Grown Virus
Identifieur interne : 002C00 ( Main/Exploration ); précédent : 002B99; suivant : 002C01Immunization of Ferrets against Influenza: A Comparison of Killed Ferret Grown and Egg Grown Virus
Auteurs : C. Sweet ; J. Stephen ; H. SmithSource :
- British Journal of Experimental Pathology [ 0007-1021 ] ; 1974.
Abstract
Both killed unadjuvanted ferret and egg grown A/Moscow/1019/65 (H2N2) influenza virus failed to immunize ferrets against challenge with homologous virus; the preparations were given in 2 doses, 2 weeks apart, distributed intranasally, intramuscularly and intraperitoneally. However, small doses (<2 HA units) of both preparations induced immunity in ferrets previously “primed” with a live heterologous virus (A/FM/1/47 (H1N1)) according to the method of Potter
These results are discussed in relation to the possibility that a previously unrecognized antigen different from haemagglutinin and neuraminidase may contribute to immunity to influenza.
Url:
PubMed: 4422501
PubMed Central: 2072627
Affiliations:
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